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Title   쥐의 전이성 간암 모델에서 자가 종양 백신을 이용한 면역 치료 ( Specific Immunotherapy Using Autologous Tumor Vaccine Treats Mutine Metastatic Hepatic Cancer )
Publicationinfo   1999 Jan; 031(02): 360-367.
Key_word   Autologous tumor vaccine, Hepatic metastases, GM-CSF
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Abstract   Purpose: Antitumor effect of granulocyte macrophage colony-stimulating factor (GM-CSF)- producing murine colon cancer cells was elucidated against intrahepatic challenge of parental cancer cells, which is clinically relevant tumor model. Materials and Methods: Using a model of liver metastasis by intrahepatic challenge of CT-26 murine colon carcinoma cells to syngeneic BALB/c mice, GM-CSF producing cells were given as a intradermal vaccine either 14 days prior to hepatic challenge, or in animals with established tumors. Tumor volume and survival were determined. Results: Animals receiving vaccination showed significant systemic protection against the hepatic challenge of parental tumor cells, and in animals with established hepatic tumors significant response was observed with some prolongation in survival. Conclusion: It is concluded that GM-CSF-producing autologous tumor vaccine was effective for the protection of host agaisnt the metastatic hepatic tumor model. Even though its efficacy against the established tumor was not as significant as in protection, GM-CSF producing autologous tumor vaccine can provide support for the specific immunotherapy for the metastatic liver cancer.
저 자   서광욱(Kwang Wook Suh),이봉호(Bong Ho Lee),(Michael A . Choti)